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Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse

产品编号:3142130
规格:clone C6G9, ascites fluid
包装规格:100 μL,0.2 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3142130100 μL5140
31421300.2 ML6730
产品别名

Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse

Carcinoembryonic antigen-related cell adhesion molecule 5

Cea Antibody-Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse

Cea Antibody

CEACAM5

CD66e

基本信息
MDL number
MFCD00162210
NACRES
NA.46
General description【一般描述】
Carcinoembryonic Antigen (CEA) is a member of the immunoglobulin superfamily that regulates cellular signaling and adhesion. CEA inhibits cell differentiation and subsequently facilitates tumor growth . Thus, CEA has been implicated in various cancers, including colorectal, lung and breast tumors
Monoclonal Anti-Human Carcinoembryonic Antigen (CEA) reacts specifically with human CEA (CD66e, 180 kDa) from different types of malignant tissues. The antibody detects an epitope which is resistant to 30 minute oxidation by 1% sodium periodate solution in formalin-fixed, paraffin-embedded tissue sections. Enzymatic predigestion with proteolytic enzymes enhances immunohistochemical staining with the antibody.The product reacts with medullary thyroid cancers and also associates with cell surface and cytoplasm of malignant glands in colorectal adenocarcinomas. Additionally, the product reacts weakly with normal colon mucosa and occasionally reacts with bile canalicular and pancreatic acinar cells. However, the antibody does not react with other tested tissue such as term placenta, nor does it bind to non-specific cross-reacting antigen (NCA) in granulocytes.
Carcinoembryonic Antigen (CEA) is located on human chromosome 19q13.2.
Specificity【特异性】
The antibody reacts specifically with human CEA (CD66e, 180 kDa) from several types of malignant tissue including colorectal, lung and breast tumors. It also stains medullary carcinomas of the thyroid. The product reacts strongly with the cell surface and cytoplasm of malignant glands in colorectal adenocarcinomas. A weak reactivity is seen with normal colon mucosa and occasionally with bile canalicular and pancreatic acinar cells, but not with other tested tissue including term placenta. There is no cross-reactivity with non-specific cross-reacting antigen (NCA) present in granulocytes, using immunoblotting, flow cytometry and immunohistochemical techniques. The antibody recognizes an epitope that is resistant to 30 minute oxidation by 1% sodium periodate solution in routine formalin-fixed and paraffin-embedded tissue sections. Enzymatic predigestion with proteolytic enzymes improves immunohistochemical staining with the antibody.
Immunogen【免疫原】
carcinoembryonic antigen (CEA) isolated from a human colon adenocarcinoma cell line.
Application【应用】
Monoclonal Anti-Carcinoembryonic Antigen antibody is suitable for use in immunohistochemistry (1:8,000 using formalin-fixed, paraffin-embedded sections of human colon carcinoma tissue).
Monoclonal Anti-Carcinoembryonic Antigen antibody produced in mouse has been used in western blot analysis and surface plasmon resonance (SPR) based immunoassay.
Biochem/physiol Actions【生化/生理作用】
Carcinoembryonic Antigen (CEA) inhibits tumor growth in colon, hepatoma and prostate cancers.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
ascites fluid
antibody product type
primary antibodies
clone【克隆】
C6G9, monoclonal
contains【包含】
15 mM sodium azide
species reactivity
human
technique(s)
flow cytometry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:8,000 using human colon carcinoma tissue
western blot: suitable
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
P13688
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CEACAM5(1048)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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