Monoclonal Anti-C19orf62 antibody produced in mouse

NA.41

Recombinant protein encompassing a sequence within the N-terminus region of human C19orf62.

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Component of the BRCA1-A complex, a complex that specifically recognizes ′Lys-63′-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ′Lys-63′-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ′Lys-63′-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.

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Purification: Affinity purified by Protein G

Phosphate-buffered saline, no preservative added.

100

mouse

unconjugated

affinity isolated antibody

primary antibodies

GT1251, monoclonal

buffered aqueous solution

human

1mg/mL

indirect immunofluorescence: suitable
western blot: 500-3000

IgG2a

Q9NWV8

wet ice

−20℃

human ... BABAM1(29086)

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12 - Non Combustible Liquids

WGK 1