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Monoclonal Anti-Brg1 antibody produced in rat

产品编号:3141821
规格:clone 3G4, purified from hybridoma cell culture
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3141821100 μL6670
产品别名

Monoclonal Anti-Brg1 antibody produced in rat

Anti-BRG1

Anti-RTPS2

Anti-member 4

Anti-protein brahma homolog 1

Anti-transcription activator BRG1

Anti-SNF2

Anti-SMARCA4

Anti-SWI/SNF related

Anti-ATP-dependent helicase SMARCA4

Anti-brahma protein-like 1

Anti-hSNF2b

Anti-SWI2

Anti-sucrose nonfermenting-like 4

Anti-nuclear protein GRB1

Anti-homeotic gene regulator

Anti-BRM/SWI2-related gene 1

Anti-SNF2L4

Anti-actin dependent regulator of chromatin

Anti-BAF190

Anti-SNF2-like 4

Anti-BAF190A

Anti-protein BRG-1

Anti-mitotic growth and transcription activator

Anti-MRD16

Anti-SNF2LB

Anti-subfamily a

Anti-SNF2-BETA

Anti-global transcription activator homologous sequence

Anti-matrix associated

Anti-BRG1-associated factor 190A

基本信息
NACRES
NA.41
General description【一般描述】
Monoclonal Anti-Brg1 (rat IgG1 isotype) is derived from the hybridoma 3G4 produced by the fusion of mouse myeloma cells (SP2) and lymph node cells from rat immunized with a synthetic peptide corresponding to a sequence at the C-terminal region of human Brm-related gene-1 (Brg1) protein. Brg1 or SWI/SNF (SWItch/Sucrose non-fermentable) related, matrix-associated, actin-dependent, regulator of chromatin, subfamily A, member 4 (SMARCA4) gene with 35 exons, is encoded by the gene mapped to human chromosome 19p13.
Immunogen【免疫原】
a synthetic peptide corresponding to a sequence at the C-terminal region of human Brg1 protein
Application【应用】
Monoclonal Anti-Brg1 antibody produced in rat has been used in:
  • immunoblotting (~185 kDa)
  • flow cytometry
  • immunofluorescence

Biochem/physiol Actions【生化/生理作用】
Brm-related gene-1 (Brg1) (or hBrm) protein is the central catalytic ATPase of the SWI/SNF chromatin-remodeling complex, which is involved in transcriptional modulation of hormone-responsive promoters through binding of the complex to various nuclear receptors and its recruitment to gene-specific promoters. In addition, BRG1 has also been shown to act as a transcriptional repressor. It interacts with retinoblastoma tumor suppressor to form a repressor complex which inhibits cell cycle proteins such as cyclins A, D1 and E. BRG1 participates in the firing of origins and the process of replication elongation. This function of BRG1 also facilitates embryogenesis. In addition, It functions as a tumor suppressor and maintains genome stability and prevent cancer.
Physical form【外形】
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
3G4, monoclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
~185 kDa
species reactivity
mouse, human
concentration【浓度】
~1 mg/mL
technique(s)
flow cytometry: 2.5-5 μg/test using HeLa cells
immunoblotting: 0.1-0.2.0 μg/mL using HeLa nuclear extract
immunofluorescence: 10 μg/mL using HeLa cells
isotype【同位素/亚型】
IgG1
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... BRG1(6597)
mouse ... Brg1(20586)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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