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Monoclonal Anti-Bone Morphogenetic Protein 6 antibody produced in mouse
| 产品编号： | 3141765 |
| 规格： | clone 74219.11, purified immunoglobulin, lyophilized powder |
| 包装规格： | 500 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-Bone Morphogenetic Protein 6 antibody produced in mouse
Anti-BMP-6
基本信息
| MDL number | MFCD01321772 |
| NACRES | NA.41 |
| General description【一般描述】 | Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP-6 regulates both T cell and B cell-mediated immunity. It acts through Smad and p38 pathway to induce the expression of IL-6. Additionally, it induces the expression of iNOS by macrophages through the activation of NF-κB and STAT pathways. BMP-6 is a stimulator of differentiation of liver, bone, neuronal tissue and embryonic kidney and urinary systems. Studies also indicate that BMP-6 is important in the regulation of liver hormone, hepcidin, expression that is important to maintain systemic iron balance Monoclonal Anti-Bone Morphogenetic Protein 6 recognizes human BMP-6. The antibody shows no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, and rhBMP-7. |
| Immunogen【免疫原】 | recombinant human BMP-6. |
| Application【应用】 | Anti-Bone Morphogenetic Protein 6 antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. For capture ELISA a concentration of 4 μg/ml is recommemnded. The antibody is also suitable for neutralization reactions. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
| Preparation Note【制备说明】 | Purified using protein G. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 74219.11, monoclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | capture ELISA: suitable neutralization: suitable western blot: 1-2 μg/mL |
| isotype【同位素/亚型】 | IgG2b |
| UniProt accession no.【UniProt登记号】 | P22004 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BMP6(654) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
