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Monoclonal Anti-BNIPL, (N-terminal) antibody produced in mouse
| 产品编号： | 3141754 |
| 规格： | clone 2C8, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-BNIPL, (N-terminal) antibody produced in mouse
PP753
BNIPL-2
BNIP-S
BNIPL2
BNIPl-1
BNIPL1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The gene BNIPL (Bcl-2/adenovirus E1B 19kDa interacting protein 2-like) encodes a protein containing BNIP-2 and Cdc42GAP homology (BCH) domain and has a molar mass of 19kDa. It is abundantly expressed in human placenta and lung. |
| Immunogen【免疫原】 | BNIPL (AAH27868, 1 a.a. ~ 275 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MRKRLSAPELRLSLTKGPGNDGASPTQSAPSSPDGSSDLEIDELETPSDSEQLDSGHEFEWEDELPRAEGLGTSETAERLGRGCMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLISLDQVHIPEAVRQLDRDLHGSGGT |
| Biochem/physiol Actions【生化/生理作用】 | The gene BNIPL (Bcl-2/adenovirus E1B 19 kDa interacting protein 2-like) encodes a protein of the BNIPL family that functions in the apoptotic pathway. The BCH (BNIP-2 and Cdc42GAP homology) domain plays a crucial role by interacting with Bcl-2 and Cdc42GAP and inducing cell death. It serves as a linker protein in Bcl-2 pathway for DNA fragmentation. It also participates in Cdc42 (cell division control) signaling for changes in cell morphology and membrane blebbing during apoptosis. It facilitates invasion and cancer metastasis. |
| Physical form【外形】 | Solution in phosphate buffered saline, pH 7.4 |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 2C8, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~56.36 kDa |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable western blot: 1-5 μg/mL |
| isotype【同位素/亚型】 | IgG2aκ |
| NCBI accession no.【NCBI登记号】 | BC027868 |
| UniProt accession no.【UniProt登记号】 | Q7Z465 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BNIPL(149428) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
