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Monoclonal Anti-BIRC5 antibody produced in mouse
产品别名
Monoclonal Anti-BIRC5 antibody produced in mouse
EPR-1
BIRC5
API4
基本信息
NACRES | NA.41 |
General description【一般描述】 | BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5 ), also known as Survivin, is a transmembrane glycoprotein receptor encoded by the BIRC5 gene in humans. It consists of a unique cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich (26%) cytoplasmic tail with at least 15 potential phosphorylation sites. |
Immunogen【免疫原】 | Purified recombinant fragment of Survivin expressed in E.coli. Mouse monoclonal antibody raised against Survivin |
Application【应用】 | Monoclonal Anti-BIRC5 antibody produced in mouse is suitable for direct ELISA (1:10,000), flow cytometry (1:200-1:400), immunohistochemistry (1:200-1:1,000), indirect immunofluorescence (1:200-1:1,000) and western blot (1:500-1:2,000). |
Biochem/physiol Actions【生化/生理作用】 | BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5) functions as a cell surface receptor for factor Xa. It is predicted to be a potential factor in protease-dependent cellular effector functions.It also behaves as a receptor for factor Xa during the cell surface assembly of proteolytic activities and leukocyte mitogenesis. A study reports that the expression of BIRC5 can be controlled by mRNA splicing. It is an inhibitor of apoptosis and is expressed in various malignancies. |
Physical form【外形】 | Ascitic fluid containing 0.03% sodium azide. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | ascites fluid |
antibody product type | primary antibodies |
clone【克隆】 | 2H5H2, monoclonal |
species reactivity | human |
technique(s) | direct ELISA: 1:10,000 western blot: 1:500-1:2,000 |
isotype【同位素/亚型】 | IgG1 |
shipped in【运输】 | wet ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... BIRC5(332) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 3 |