Monoclonal Anti-APC antibody produced in mouse

MFCD01322509

NA.41

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. (provided by RefSeq)
Adenomatous polyposis coli protein (APC) is encoded by the gene mapped to human chromosome 5q. The encoded protein is composed of 2843 amino acids. APC exists as many transcripts and they are expressed in tissue specific manner.

APC (NP_000029, 2744 a.a. ~ 2843 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
NPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV

Adenomatous polyposis coli protein (APC) is a tumor suppressor gene. It plays an important role in cell division, adhesion and migration. Mutations in this gene are associated with familial adenomatous polyposis (FAP). APC is involved with Wnt pathway and inhibits the molecules which induce β-catenin expression, an agent participating in cellular transformation. It also regulates metaphase-anaphase transition, mitotic exit and G1 phase, thereby maintaining genomic stability and chromosome segregation.

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Solution in phosphate buffered saline, pH 7.4

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100

mouse

unconjugated

purified immunoglobulin

primary antibodies

3E2, monoclonal

buffered aqueous solution

human

immunofluorescence: suitable
indirect ELISA: suitable
proximity ligation assay: suitable
western blot: 1-5 μg/mL

IgG1κ

NM_000038

P25054

dry ice

−20℃

human ... APC(324)

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12 - Non Combustible Liquids

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)