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LM11A-31 dihydrochloride
产品别名
1214672-15-7
LM11A-31 dihydrochloride
2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H25N3O2 · 2HCl |
| Molecular weight | 316.27 |
| MDL number | MFCD11505486 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825578 |
| NACRES | NA.77 |
| Application【应用】 | LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability. |
| Biochem/physiol Actions【生化/生理作用】 | LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | oil |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | colorless to yellow |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1 |
| InChI | 1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H |
| InChI key | LLIHJRRZJDEKLB-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 - H410 |
| Precautionary Statements | P273 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
