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Insulin-Like Growth Factor Binding Protein-2 from mouse
| 产品编号： | 3099608 |
| 规格： | ≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture |
| 包装规格： | 25 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Insulin-Like Growth Factor Binding Protein-2 from mouse
IGFBP-2
基本信息
| MDL number | MFCD02099094 |
| NACRES | NA.32 |
| General description【一般描述】 | IGFBP2 (insulin-like growth factor binding protein 2) belongs to the IGFBP family of proteins. The protein has two HBD (heparin-binding domain-1) domains. It is a secreted protein. |
| Biochem/physiol Actions【生化/生理作用】 | IGFBP2 (insulin-like growth factor binding protein 2) works along with IGF-I (insulin like growth factor I) and regulates cellular proliferation and differentiation. It mainly binds to IGFs and restricts their association to other receptors. During development, insulin-like growth factor binding protein-2 is expressed in a number of tissues with the highest expression level found in the central nervous system. IGFBP-2 exhibits a 2-10 fold higher affinity for IGF II than for IGF I. Mouse and human IGFBP-2 share approximately 82% homology. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution of 35% acetonitrile and 0.1% TFA. |
| Analysis Note【分析说明】 | The biological activity is measured by its ability to inhibit recombinant human lGF-II on MCF-7 cells. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| recombinant【重组】 | expressed in NSO cells |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| potency【效能】 | 0.125-0.5 mg per mL ED50 |
| mol wt【分子量】 | ~35 kDa by SDS-PAGE (reducing) calculated mol wt 29.4 kDa |
| packaging【包装】 | pkg of 25 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities【杂质】 | endotoxin, tested |
| UniProt accession no.【UniProt登记号】 | D3YU40 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | mouse ... Igfbp2(16008) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
