IL-6 from mouse

NA.32

Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.

IL-6 from mouse has been used to study IL-6-mediated inhibition of mouse preadipocyte differentiation.

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R and gp130.

Lyophilized from 0.1% TFA

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

mouse

expressed in E. coli

≥98% (HPLC)
≥98% (SDS-PAGE)

lyophilized

5x10^7 units/mg ED₅₀

21.7 kDa

pkg of 10 μg

endotoxin, tested

white to off-white

P08505

wet ice

−20℃

mouse ... IL6(16193)

13 - Non Combustible Solids

WGK 3