Ibandronate 钠盐 一水合物

C₉H₂₂NNaO₇P₂

341.21

MFCD07197214

329815388

NA.77

Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.

Ibandronate sodium inhibits farnesyl diphosphate synthase (IC₅₀ = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

100

≥97% (NMR)

solid

protect from light

white

H₂O: >10 mg/mL

Roche

2-8℃

[Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O

1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1

LXLBEOAZMZAZND-UHFFFAOYSA-M

human ... FDPS(2224)

10, 50 mg in glass bottle

13 - Non Combustible Solids

WGK 3