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GW843682X
产品编号: | 3094231 |
规格: | ≥98% (HPLC), solid |
CAS NO: | 660868-91-7 |
包装规格: | 1 MG,5 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品价格查看更多规格...
产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
3094231 | 1 MG | 1830 | |||
3094231 | 5 MG | 6690 |
产品别名
660868-91-7
GW843682X
GW843682
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide
结构式
基本信息
Empirical Formula【经验(实验)分子式】 | C22H18F3N3O4S |
Molecular weight | 477.46 |
MDL number | MFCD09971143 |
PubChem Substance ID【PubChem化学物质编号】 | 329799898 |
NACRES | NA.77 |
Application【应用】 | GW843682X has been used as a polo-like kinase-1 (PLK1) inhibitor:
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Biochem/physiol Actions【生化/生理作用】 | GW843682X is an anti-cancer compound. It can improve the ability of vincristine to promote growth arrest and apoptosis in leukemia cells. GW843682X is capable of disturbing the formation of spindles and terminate mitoses in lung adenocarcinoma cells. GW843682X is a polo-like kinase-1 (PLK1) and polo-like kinase-3 (PLK3) inhibitor with nanomolar activity. It shows potent inhibition of proliferation of a wide variety of tumor cell lines. |
Features and Benefits【特点和优势】 | This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥98% (HPLC) |
form【形式】 | solid |
color【颜色】 | off-white |
solubility【溶解性】 | DMSO: >10 mg/mL |
originator【创始人】 | GlaxoSmithKline |
storage temp.【储存温度】 | 2-8℃ |
SMILES string | COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC |
InChI | 1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29) |
InChI key | JSKUWFIZUALZLX-UHFFFAOYSA-N |
packaging【包装】 | 1, 5 mg in glass bottle |
安全信息
Pictograms【象形图】 | GHS07 |
Signal word【警示用语:】 | Warning |
Hazard Statements | H315 - H319 - H335 - H413 |
Precautionary Statements | P261 - P305 + P351 + P338 |
Hazard Classifications【危险分类】 | Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 3 |
Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |