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GSK4112

产品编号:3094052
规格:≥98% (HPLC)
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
30940525 MG2400
309405225 MG7020
产品别名

GSK4112

1,1-Dimethylethyl N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate

SR6452

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C18H21ClN2O4S
Molecular weight
396.89
MDL number
MFCD12912412
PubChem Substance ID【PubChem化学物质编号】
329799818
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.
Features and Benefits【特点和优势】
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
off-white to tan
solubility【溶解性】
DMSO: >20 mg/mL
originator【创始人】
GlaxoSmithKline
storage temp.【储存温度】
2-8℃
SMILES string
CC(C)(C)OC(=O)CN(Cc1ccc(Cl)cc1)Cc2ccc(s2)[N+]([O-])=O
InChI
1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3
InChI key
WYSLOKHVFKLWOU-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Pictograms【象形图】
GHS05,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H318 - H334
Precautionary Statements
P261 - P280 - P305 + P351 + P338 - P342 + P311
Hazard Classifications【危险分类】
Eye Dam. 1 - Resp. Sens. 1
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 1
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