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Glycophorin Predominantly glycophorin A 来源于 MN 型血液

Glycophorin Predominantly glycophorin A from blood type MN
产品编号:3091733
规格:lyophilized powder
CAS NO:76416-15-4
包装规格:0.5 MG,1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
30917330.5 MG4570
30917331 MG8030
产品别名

76416-15-4

Glycophorin Predominantly glycophorin A 来源于 MN 型血液

Glycophorin Predominantly glycophorin A from blood type MN

基本信息
MDL number
MFCD00131223
NACRES
NA.61
General description【一般描述】
Glycophorin A cconsists of a glycosylated extracellular domain, a single transmembrane α-helix and a cytoplasmic COOH-terminal domain.
Glycophorin (GYPA), a sialoglycoprotein, is present in human erythrocytes that carry antigens M and N of the MN blood group. The GYPA gene is mapped to human chromosome 4q31.21.
Application【应用】
Glycophorin A (GpA) is used as a model system for extensive experimental, theoretical, and simulation studies focusing on TM protein association. Glycophorin A is used to study the mechanism of kinase activation in the receptor for colony-stimulating factor 1. It is used to analyse glycoproteins separated by two-dimensional gel electrophoresis.
Glycophorin Predominantly glycophorin A from blood type MN has been used:
  • as a standard in Amide-80 column size-based separation for the characterization of plasma-type O-linked sugar chains
  • to screen the P. falciparum phage library using biopanning method,
  • as a phosphocholine-free component to test its reactivity with antibodies over a saccharide-bound enzyme-linked immunosorbent assay (ELISA)

Biochem/physiol Actions【生化/生理作用】
Glycophorin (GYPA) is involved in the mode of entry of the Plasmodium falciparum parasite into erythrocytes. It is also implicated in intraplaque hemorrhage as well as in the macrophage infiltration in coronary atheromas.
A membrane glycoprotein with several isoforms that interact with other membrane proteins to confer shape and antigenicity to erythrocytes.
产品性质
biological source【生物来源】
human blood (type MN)
Quality Level【质量水平】
200
form【形式】
lyophilized powder
solubility【溶解性】
soluble 1.00-1.10 mg/mL
H2O: soluble, clear to hazy
UniProt accession no.【UniProt登记号】
P02724
storage temp.【储存温度】
−20℃
Gene Information
human ... GYPA(2993)
packaging【包装】
0.5, 1 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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