GITRL, Soluble mouse

NA.32

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Solution in 10 mM glycine, pH 10.0.

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG^®-tag.

FLAG is a registered trademark of sigma-aldrich Co. LLC

mouse

expressed in HEK 293 cells

FLAG^® tagged

>90% (SDS-PAGE)

liquid

~22 kDa by SDS-PAGE

pkg of 50 μg

avoid repeated freeze/thaw cycles

≥0.2 mg/mL

<0.1 EU/μg endotoxin, tested

clear

Q7TS55

wet ice

−20℃

mouse ... Tnfsf18(240873)

12 - Non Combustible Liquids

WGK 1