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Galeterone
产品别名
851983-85-2
Galeterone
VN/124-1
VN-124-1
TOK-001
3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H32N2O |
| Molecular weight | 388.55 |
| MDL number | MFCD16660907 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825826 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Galeterone is an inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17-α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Galeterone, moreover, is a potent blocker of the androgen receptor and causes down-regulation of androgen receptor (AR) protein expression in vitro and in vivo. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | C[C@]12C(C[C@@H](O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4N5C=NC6=C5C=CC=C6 |
| InChI | 1S/C26H32N2O/c1-25-13-11-18(29)15-17(25)7-8-19-20-9-10-24(26(20,2)14-12-21(19)25)28-16-27-22-5-3-4-6-23(22)28/h3-7,10,16,18-21,29H,8-9,11-15H2,1-2H3/t18-,19-,20-,21-,25-,26-/m0/s1 |
| InChI key | PAFKTGFSEFKSQG-PAASFTFBSA-N |
| Gene Information | human ... AR(367), CYP17A1(1586) |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
