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EVP4593

产品编号:3086511
规格:≥98% (HPLC)
CAS NO:545380-34-5
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
30865115 MG1650
308651125 MG6060
产品别名

545380-34-5

EVP4593

QNZ

4-N-[2-(4-Phenoxyphenyl)ethyl]quinazoline-4,6-diamine

N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C22H20N4O
Molecular weight
356.42
MDL number
MFCD06411436
PubChem Substance ID【PubChem化学物质编号】
329825563
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.
Features and Benefits【特点和优势】
This compound is featured on the Calcium Channels, Cytokine Receptors (Interleukin-1 Receptor/TIR Family) and Cytokine Receptors (Tumor Necrosis Receptor Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Other Notes【其他说明】
Air sensitive
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
storage condition【储存条件】
desiccated
color【颜色】
white to beige
solubility【溶解性】
DMSO: 15 mg/mL, clear
storage temp.【储存温度】
2-8℃
SMILES string
NC1=CC(C(NCCC2=CC=C(OC3=CC=CC=C3)C=C2)=NC=N4)=C4C=C1
InChI
1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
InChI key
IBAKVEUZKHOWNG-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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