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DIF-3

产品编号:3077066
规格:≥99% (HPLC), solid
CAS NO:113411-17-9
包装规格:1 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
30770661 MG1640
产品别名

113411-17-9

DIF-3

Differentiation-inducing factor 3

1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C13H17ClO4
Molecular weight
272.72
MDL number
MFCD05865230
PubChem Substance ID【PubChem化学物质编号】
24724455
General description【一般描述】
Differentiation-inducing factor-3 (DIF-3) is a monochlorinated metabolite of differentiation-inducing factor-1 (DIF-1), that belongs to the differentiation-inducing factor (DIF) family.
Application【应用】
DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes
Biochem/physiol Actions【生化/生理作用】
Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.
DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥99% (HPLC)
form【形式】
solid
solubility【溶解性】
DMSO: soluble 46 mg/mL
SMILES string
CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O
InChI
1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3
InChI key
JWBMZIJMSBFBIY-UHFFFAOYSA-N
packaging【包装】
1 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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