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脱氧胆酸

Deoxycholic Acid
产品编号:3074967
规格:≥99.0% (T)
CAS NO:83-44-3
包装规格:25 G,100 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
307496725 G749
3074967100 G1720
产品别名

83-44-3

脱氧胆酸

Deoxycholic Acid

7-Deoxycholic acid

Desoxycholic acid

3α,12α-Dihydroxy-5β-cholanic acid

7-脱氧胆酸

3α,12α-二羟基-5β-胆汁酸

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C24H40O4
Molecular weight
392.57
Beilstein
3219882
EC number【EC 号】
201-478-5
MDL number
MFCD00003673
PubChem Substance ID【PubChem化学物质编号】
329753610
NACRES
NA.77
General description【一般描述】
Deoxycholic acid is an amphiphilic molecule and an important constituent of bile acid. It contains hydroxyl groups substituted at the 3α and 12α positions and a carboxyl group towards the end of the branched-chain. These moieties contribute to the hydrophilic nature of the molecule and the hydrophobic cyclopentanophenanthrene forms its center.
Application【应用】
Deoxycholic acid has been used as:
  • a hyphal-inhibitory compound in an ex vivo assay to study the hyphal morphogenesis of Candida albicans in the gastrointestinal tract
  • an internal standard to estimate the toxin concentration in the cell pellet
  • a bile acid (BA) standard to quantitatively measure BA in various samples from treated mice by ultra-performance liquid chromatography triple quadrupole mass spectrometry

Biochem/physiol Actions【生化/生理作用】
Deoxycholic acid, due to its amphiphilicity, significantly helps to solubilize, emulsify, and absorb fat, vitamins, and cholesterol in the body. High levels of intestinal deoxycholic acid might cause colorectal cancer by inducing oxidative stress and leading to DNA damage. It acts as an oncogene and pro-tumor factor.
Other Notes【其他说明】
用于β-肾上腺素能受体的增溶
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
ox bile
description【描述】
anionic
Assay【测定】
≥99.0% (T)
form【形式】
powder
optical activity【旋光性】
[α]20/D +54±1°, c = 1% in ethanol
mol wt【分子量】
392.57 g/mol
impurities【杂质】
≤1% cholic acid (TLC)
mp
170-175 ℃
171-174 ℃ (lit.)
functional group【官能团】
carboxylic acid
SMILES string
C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
InChI
1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1
InChI key
KXGVEGMKQFWNSR-LLQZFEROSA-N
Gene Information
human ... ATIC(471)
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H302
Precautionary Statements
P301 + P312 + P330
Hazard Classifications【危险分类】
Acute Tox. 4 Oral
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
dust mask type N95 (US), Eyeshields, Gloves
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