广州伟伯科技有限公司
您的位置:首页 > 产品中心 > 4342-03-4, 达卡巴嗪
产品搜索:

达卡巴嗪

Dacarbazine
产品编号:3074459
规格:antineoplastic purine analog
CAS NO:4342-03-4
包装规格:100 MG,1 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
3074459100 MG823
30744591 G3330
产品别名

4342-03-4

达卡巴嗪

Dacarbazine

DTIC

5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C6H10N6O
Molecular weight
182.18
EC number【EC 号】
224-396-1
MDL number
MFCD00057167
PubChem Substance ID【PubChem化学物质编号】
24893683
NACRES
NA.85
Application【应用】
Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.
Biochem/physiol Actions【生化/生理作用】
Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.
Other Notes【其他说明】
Keep container tightly closed in a dry and well-ventilated place.
产品性质
Quality Level【质量水平】
100
form【形式】
powder or crystals
solubility【溶解性】
1 M HCl: 50 mg/mL
Mode of action【作用机制】
DNA synthesis | interferes
antibiotic activity spectrum【抗生素抗菌谱】
neoplastics
storage temp.【储存温度】
2-8℃
SMILES string
CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI
1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key
FDKXTQMXEQVLRF-ZHACJKMWSA-N
packaging【包装】
1 g in glass bottle
100 mg in glass bottle
安全信息
Pictograms【象形图】
GHS07,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H302 + H312 + H332 - H315 - H319 - H335 - H340 - H350
Precautionary Statements
P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Classifications【危险分类】
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Skin Irrit. 2 - STOT SE 3
Target Organs【靶器官】
Respiratory system
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0081