CyPPA

C₁₆H₂₃N₅

285.39

MFCD01550586

329775087

NA.77

CyPPA has been used:

• to test its inhibitory functionality on melanogenesis
• as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
• in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells

CyPPA is a positive modulator of small conductance Ca²⁺-activated K⁺ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC₅₀ of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

100

≥98% (HPLC)

solid

white

DMSO: >10 mg/mL
H₂O: <2 mg/mL

2-8℃

Cc1cc(NC2CCCCC2)nc(n1)-n3nc(C)cc3C

1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)

USEMRPYUFJNFQN-UHFFFAOYSA-N

5, 25 mg in glass bottle

GHS07

Warning

H315 - H319 - H335 - H413

P273 - P302 + P352 - P305 + P351 + P338

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3

dust mask type N95 (US), Eyeshields, Gloves