乙氧亚甲基丙二酸二乙酯

Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.

Incompatible with acids, bases, oxidizing agents and reducing agents.

MFCD00009148

201-725-7

C₁₀H₁₆O₅

216.23

-33°

136-139°/10mm

144°(291°F)

1.080

1.4620

Ambient temperatures.

Liquid

Miscible with chloroform, dichloromethane and methanol. Immiscible with water.

880058

22-36/38-42/43
Harmful if swallowed.Irritating to eyes and skin.May cause sensitization by inhalation and skin contact.

23-24-26-36/37-45
Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).Avoid contact with skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

OO1100000

 

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H303-H315-H319-H334-H317
May be harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause allergy or asthma symptoms or breathing difficulties if inhaled.May cause an allergic skin reaction.

P284-P261-P280a-P305+P351+P338-P304+P340-P501a
Wear respiratory protection.Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Dispose of contents/container in accordance with local/regional/national/international regulations.