4-溴苯甲腈

4-Bromobenzonitrile is used as reagents and solvents. Reaction of 2-propanol, 4-bromobenzonitrile, and NaH in the presence of 1.5 mol % Pd2(dba)3 and 3 mol % (S)-(-)2,2?-bis(di-p-tolylphosphino)- 1,1?-binaphthyl at 50?°C afforded 4-isopropoxy- benzonitrile in 80% isolated yield. The synthesis of 4-cyanobiphenyl at room temperature in a flow injection microreactor, using a supported catalyst, without the addition of a base gave a product yield of 67?±7% (n=6). This was achieved by injecting 4-bromobenzonitrile. The 3-arylation of 2,5-dimethylthiophene with 4-bromopropiophenone, 4-trifluoromethylbromobenzene or 4-bromobenzonitrile gave 3-5 in only 38-50% yields in Palladium-catalysed direct 3-or 4-arylation of thiophene derivatives using aryl bromides.

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

MFCD00001811

210-764-9

C₇H₄BrN

182.03

111-114°

235-237°

130°(266°F)

1.562

Ambient temperatures.

Crystalline powder

Very slightly soluble in water(0.2g/L). Soluble in alcohol and ether.

2041518

20/21/22-36/37/38-52/53
Harmful by inhalation, in contact with skin and if swallowed.Irritating to eyes, respiratory system and skin.Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

26-36/37-61
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.Avoid release to the environment. Refer to special instructions/safety data sheets.

DI2460000

 

否

 

H301-H312-H331-H315-H319-H335-H402-H412
Toxic if swallowed.Harmful in contact with skin.Toxic if inhaled.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.Harmful to aquatic life.Harmful to aquatic life with long lasting effects.

P261-P280-P301+P310a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.