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SILuTMLite IL6 Interleukin 6 human
| 产品编号： | 4169076 |
| 规格： | recombinant, expressed in HEK 293 cells, MS protein standard |
| 包装规格： | 50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
SILuTMLite IL6 Interleukin 6 human
IL-6
Interferon beta-2 (IFN-beta-2)
B-cell stimulatory factor 2 (BSF-2)
Hybridoma growth factor
CTL differentiation factor (CDF)
基本信息
| NACRES | NA.12 |
| General description【一般描述】 | SILu™ Lite IL-6 is a recombinant human protein expressed in human 293 cells. It is a monomer of 183 amino acids, with a molecular weight of ~21 kDa. SILu™ Lite IL-6 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications. Suggested Quantitative Analysis Parameters (MRM settings provided for three suggested peptides) |
| Biochem/physiol Actions【生化/生理作用】 | IL-6 is an abundant cytokine, which is crucial for leukocyte and endothelial cell activation. IL-6 is one of the major cytokines that are implicated clinically as biomarkers in ACS (Acute Coronary Syndrome). Its pathophysiological contribution to ACS is the induction of acute-phase response. Patients with ACS have increased circulating levels of IL-6 compared with those patients who have stable angina. Among patients with unstable angina, an increase in IL-6 levels that occurred 48 hours after admission compared with the admission value was associated with the combined end point of death, myocardial infarction (MI), or refractory angina. High levels of IL-6 are also related to cardiovascular disease, heart attack, and stroke. |
| Sequence【序列】 | VPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM |
| Physical form【外形】 | Supplied as a lyophilized powder containing phosphate buffered saline. |
| Legal Information【法律信息】 | This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com. SILu is a trademark of sigma-aldrich Co. LLC |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| Assay【测定】 | ≥98% (SDS-PAGE) |
| form【形式】 | lyophilized powder |
| mol wt【分子量】 | 20812.7 |
| technique(s) | mass spectrometry (MS): suitable |
| suitability【适用性】 | suitable for mass spectrometry (internal calibrator) |
| UniProt accession no.【UniProt登记号】 | P05231 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL6(3569) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
