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产品性质
| biological source【生物来源】 | human |
| description【描述】 | Method (N/A) age (N/A) |
| manufacturer/tradename | EBiSC™ |
| gender【性别】 | female |
| growth mode【生长模式】 | adherent (pluripotent) |
| technique(s) | cell culture | stem cell: suitable |
| relevant disease(s)【相关疾病】 | Alzheimer′s disease |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −196℃ |
基本信息
| General description【一般描述】 | Induced pluripotent stem cells (iPSCs) are adult cells that have been reprogrammed to an embryonic stem cell–like state. The cells can replicate indefinitely or, under controlled conditions, can be differentiated into any other cell type such as nerve, heart or liver cells. Medical researchers are able to use iPS cells to test how different patients might respond to new drugs or to analyse how genetic diseases develop. The EBiSC stem cell bank is a collection of human iPS cells available to academic and commercial researchers for use in disease modelling and other forms of stem cell research. The initial collection has been generated from a wide range of donors representing specific disease backgrounds and healthy controls. EBiSC has established many routine procedures for collecting, expanding and characterizing human iPS cell lines. The stem cell bank includes iPSC cell lines derived from neurodegenerative diseases (Alzheimer′s Disease, Parkinson′s Disease, Dementia, Motor Neuron Disease (ALS) - and Huntington′s Disease), eye and heart diseases, and lines from healthy control donors for age and sex matching. |
| Cell Line Origin【细胞系来源】 | Depositor sigma-aldrich |
| Cell Line Description【细胞系描述】 | Derivation Primary cell type: - Reprogramming method Vector type: None Xeno free conditions: no Derived under gmp: no Available as clinical grade: no Characterization Analysis of Undifferentiated Cells Marker expression: Marker Expressed Immunostaining RT-PCR FACS Enzymatic Assay Expression Profiles POU5F1 (OCT-4) Yes TRA 1-60 Yes SSEA-3 Yes Microbiology / Virus Screening HIV 1: - HIV 2: - Hepatitis B: - Hepatitis C: - Mycoplasma: - Genotyping Karyotyping Karyotyping method: G-Banding Genetic Modification Disease/phenotype related modifications Disease: Alzheimer′s disease Type of modification: Isogenic Gene: MAPT Chromosome location: 17q21.31 Zygosity: Heterozygous Target locus modification: Mutated Description: MAPT 10+16T Mono allelic Disease: Frontotemporal dementia |
| Linkage【联系】 |
Note: EAUA and CLIP must be completed before order fulfillment |
| Legal Information【法律信息】 | EBiSC is a trademark of Fraunhofer-Gesellschaft |
安全信息
| Storage Class Code【储存分类代码】 | 6.2 - Infectious substances |
| WGK | WGK 3 |
