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Pomalidomide-C6-NH2 hydrochloride
产品别名
2375194-37-7
Pomalidomide-C6-NH2 hydrochloride
Protein degrader building block for PROTAC research
Pomalidomide conjugate
Template for synthesis of targeted protein degrader
4-((6-Aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Crosslinker-E3 Ligase ligand conjugate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H24N4O4 · xHCl |
| Molecular weight | 372.42 (free base basis) |
| Application【应用】 | Protein degrader building block Pomalidomide-C6-NH2 hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant amine for reactivity with an acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| Other Notes【其他说明】 | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation Discovery of MD-224 as a First-in-Class, Highly Potent and Efficacious PROTAC MDM2 Degrader Capable of Achieving Complete and Durable Tumor Regression |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Assay【测定】 | ≥95% |
| form【形式】 | powder |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NCCCCCCN)=O)NC1=O.Cl |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H360D |
| Precautionary Statements | P201 - P308 + P313 |
| Hazard Classifications【危险分类】 | Repr. 1B |
| Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
