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Amiloride, Hydrochloride-CAS 2016-88-8-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4143761 | 100 MG | 1210 |
产品别名
2016-88-8
Amiloride, Hydrochloride-CAS 2016-88-8-Calbiochem
Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
基本信息
| Empirical Formula【经验(实验)分子式】 | C6H8ClN7O · xHCl |
| Molecular weight | 229.63 (free base basis) |
| NACRES | NA.77 |
| General description【一般描述】 | An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway. An inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target capillary morphogenesis Product does not compete with ATP. Cell permeable: no Reversible: yes Target IC50: 130 µM inhibiting capillary morphogenesis completely and reversibly |
| Warning【警告】 | Toxicity: Toxic (F) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Knoll, A., et al. 1999. Microvasc. Res.58, 1. Swiercz, R., et al. 1999. Oncol. Rep.6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem.263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun.154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol.250, C175. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | off-white to yellow |
| solubility【溶解性】 | water: 2.5 mg/mL DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 10-30℃ |
| InChI | 1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H |
| InChI key | ACHKKGDWZVCSNH-UHFFFAOYSA-N |
| packaging【包装】 | 100 mg in Alu drum |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
