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RhoA,His 标记 人
RhoA, His tagged human
产品编号: | 4140343 |
规格: | recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
包装规格: | 50 μG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
RhoA,His 标记 人
RhoA, His tagged human
RHOH12
ARH12
RHO12
ARHA
基本信息
NACRES | NA.32 |
General description【一般描述】 | Ras homolog family member A (RhoA) is a small GTPase which is part of the Rho gene family. The gene encoding it is localized on human chromosome 3p21.31. |
Application【应用】 | RhoA, His tagged human has been used for in vitro kinase assay. |
Biochem/physiol Actions【生化/生理作用】 | Ras homolog family member A (RhoA) interacts with protein kinases and serves as a target of activated GTPase. RhoA plays an important role in the initial events of cell protrusion. Rho mediates corneal epithelial migration in response to external stimuli by regulating the organization of the actin cytoskeleton. The inhibition of RhoA signaling is required for both vaccinia morphogenesis and virus-induced cell motility. Vaccinia inhibits RhoA signaling using the viral protein F11 and this can enhance the spread of infection. The protein has a role in basal body docking and planar polarization. |
Physical form【外形】 | Supplied in 50mM MOPS, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Preparation Note【制备说明】 | after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles |
产品性质
biological source【生物来源】 | human |
recombinant【重组】 | expressed in E. coli |
Assay【测定】 | ≥70% (SDS-PAGE) |
form【形式】 | buffered aqueous glycerol solution |
mol wt【分子量】 | ~23 kDa |
NCBI accession no.【NCBI登记号】 | NM_001664 |
application(s) | cell analysis |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −70℃ |
Gene Information | human ... RHOA(387) |
安全信息
Pictograms【象形图】 | GHS07,GHS08 |
Signal word【警示用语:】 | Danger |
Hazard Statements | H315 - H319 - H360D |
Precautionary Statements | P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
Hazard Classifications【危险分类】 | Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 |
Storage Class Code【储存分类代码】 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
WGK | WGK 1 |