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产品别名
Anti-SDC3
SYND3
SDCN
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Syndecan 3 (SDC3) also known as neuronal syndecan (N-syndecan), belongs to the transmembrane heparan sulphate proteoglycan family. It is expressed predominantly in brain, and also in ovary, uterus, cartilage, skeletal muscle and pancreatic cells. In human chromosome, the gene SDC3 is localized on 1p35.2. |
| Immunogen【免疫原】 | Synthetic peptide corresponding to residues near the C terminal of human syndecan 3 |
| Application【应用】 | Anti-SDC3 has been used in western blot analysis and immunohistochemistry studies. |
| Biochem/physiol Actions【生化/生理作用】 | Syndecan 3 (SDC3) maintains cell shape and transfers signals from the cell surface to actin cytoskeleton. It depends on carbohydrate for the process. SDC3 is a potential modulator of gonadal steroid hormone function. SDC3 is a co-receptor for growth factors and extracellular matrix components like basic fibroblast growth factor, heparin binding growth-associated molecule, epidermal growth factor receptor and notch signalling ligands. Thus, SDC3 is involved in various functions like cell adhesion, cell-cell interaction and regulation of ligand-receptor binding. In brain, SDC3 regulates neurite outgrowth and neuronal migration. SDC3 is involved in formation of synapses to maintain homeostasis of feeding behaviour and body weight. SDC3 is one of the potential marker for obesity. Polymorphism is SDC3 leads to obesity and in female obesity is linked with hyperandrogenism. SDC3 binds with tissue factor pathway inhibitor (TFPI) in the cell surface of cancer cells. High expression of SDC3 and Pleiotrophin is involved in metastasis and tumor progression in pancreatic cancer. SDC3 expression is regulated by microRNA (miR-144-5p) (passenger strand) and leads to cancer cell aggressiveness in renal cancer. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous glycerol solution |
| species reactivity | mouse, rat, human |
| technique(s) | immunohistochemistry: 1:25-1:100 western blot: 1:200-1:1000 |
| accession no.【登记号】 | NP_055469 |
| UniProt accession no.【UniProt登记号】 | O75056 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... SDC3(9672) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
