Anti-MEPE Antibody, clone LFMb-33

32160702

NA.41

The protein with the gene name MEPE and the protein name of Matrix extracellular phosphoglycoprotein or Osteoblast/osteocyte factor 45 (OF45) is an important secreted protein expressed by osteoblasts which promotes mineralization in bone. New research interestingly indicates that cancer cells that over express MEPE/OF45 show an increased resistance to radiation therapy, thus OF45 is being examined as a potentially new target for sensitizing tumor cells to radiochemotherapy. MEPE/OF45 is highly expressed by osteoblasts and osteocytes and my multiple cancer cell types and regulated by growth factors such as FGF-2 which acts to lower expression of the protein in normal cells.

Recombinant protein corresponding to human MEPE.

Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected MEPE in 10 µg of SK-N-SH and U2OS cell lysate.
Immunohistochemistry Analysis: A representative lot detected MEPE in human salivary gland tissue (Dent, J., et al. (2004). Research. 83(9):664-670).
Anti-MEPE Antibody, clone LFMb-33 | MABC540 is an antibody against MEPE Antibody for use in Western Blotting, Immunohistochemistry.
Research Category
Apoptosis & Cancer

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MEPE in 10 µg of HeLa cell lysate.

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

Concentration: Please refer to lot specific datasheet.

100

mouse

purified immunoglobulin

primary antibodies

LFMb-33, monoclonal

human, mouse

immunohistochemistry: suitable
western blot: suitable

IgG1κ

NP_001171623

Q9NQ76

wet ice

human ... MEPE(56955)

~65 kDa observed. The calculated molecular weight of this protein is 58 kDa, but can be observed at ~45-62 kDa due to high glycosylation.

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 1