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Anti-Lysyl Oxidase (LOX) Antibody
| 产品编号： | 4109938 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Lysyl Oxidase (LOX) Antibody
Protein-lysine 6-oxidase, Lysyl oxidase
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Lysyl Oxidase (Protein-lysine 6-oxidase; LOX) is a member of the lysyl oxidase family and a product of the LOX gene. Lysyl oxidase is an extracellular-matrix oxidative enzyme characterized by its C-terminal LOX catalytic domain. In the presence of copper, lysyl oxidase removes amine groups from lysine residues of target substrates which include precursors of collagen and elastin. This deamination reaction produces reactive lysine residues which can then interact with similarly activated species to form covalent cross-links. Lysyl oxidase is found predominantly in the kidney, pancreas, heart, skeletal muscle, and placenta. Defective lysyl oxidase proteins play a role in cutis laxa autosomal recessive type 1 condition. Other studies have also suggested that lysyl oxidase may also be involved in intracellular signaling and may function as a tumor suppressor. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to Lysyl Oxidase (LOX). |
| Application【应用】 | Anti-Lysyl Oxidase (LOX) Antibody is an antibody against Lysyl Oxidase (LOX) for use in Western Blotting, IHC(P). Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Lysyl Oxidase (LOX) in adenocarcinoma cells of human prostate tissues. |
| Quality【质量】 | Evaluated by Western Blot in NIH/3T3 nuclear extract. Western Blot Analysis: A 1:1,000 dilution of this antibody detected Lysyl Oxidase (LOX) in 10 µg of NIH/3T3 nuclear extract. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse |
| species reactivity (predicted by homology) | rat (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_002308.2 |
| UniProt accession no.【UniProt登记号】 | P28300 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~46 kDa observed |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
