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Anti-CD11c Antibody (mouse), FITC, clone N418

产品编号:4105982
规格:clone N418, 0.5 mg/mL, from hamster(Armenian)
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4105982100 μG3510
产品别名

Anti-CD11c Antibody (mouse), FITC, clone N418

Integrin alpha-Xl, CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11c

基本信息
eCl@ss
32160702
NACRES
NA.44
General description【一般描述】
The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling throµgh ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
Immunogen【免疫原】
Immunogen information for this antibody is proprietary information.
Application【应用】
This armenian hamster monoclonal antibody Anti-CD11c (mouse), FITC, clone N418 validated for use in IP, IHC, Immunofluorescence & Flow Cytometry for the detection of CD11c.
Research Category
Inflammation & Immunology
Quality【质量】
The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 µg of this antibody detected CD11c in one million C57Bl/6 splenocytes.
Physical form【外形】
Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Size Exclusion Chromatography
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
hamster (Armenian)
conjugate【偶联物】
FITC conjugate
antibody form【抗体形式】
purified antibody
antibody product type
primary antibodies
clone【克隆】
N418, monoclonal
species reactivity
mouse
concentration【浓度】
0.5 mg/mL
technique(s)
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype【同位素/亚型】
IgG
UniProt accession no.【UniProt登记号】
Q9QXH4
shipped in【运输】
wet ice
产品说明
Storage and Stability【储存及稳定性】
It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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