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Anti-Thyroid Hormone Receptor β-1 Antibody
| 产品编号： | 4102675 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Thyroid Hormone Receptor β-1 Antibody
Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Thyroid hormone receptor β-1 operates as a hormone-dependent transcriptional regulator that binds DNA sequences and is activated by 3,5,3’-l-triiodothyronine (T3). Thyroid hormone receptor β-1 is important in vertebrate development, specifically in developing limbs and face. 9-cis-retinoic acid receptor (RXR) and retinoic acid receptor (RAR) receptor families are often associated with thyroid hormone receptor β-1 and form homodimers and heterodimers. Mutations in thyroid hormone receptor β-1 have been associated with general resistance to thyroid hormones which tend to cause significant behavioral abnormalities. Recent research has linked thyroid hormone receptor β-1 to tumor suppression, where the receptor has commonly been found to be disrupted in the occurrence of cancer. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human Thyroid Hormone receptor β-1. |
| Application【应用】 | Research Sub Category Hormones & Receptors Anti-Thyroid Hormone Receptor β-1 Antibody is a rabbit polyclonal antibody for detection of Thyroid Hormone Receptor β-1 also known as Thyroid hormone receptor beta, c-erbA-2, c-erbA-beta & has been validated in WB. Research Category Neuroscience |
| Quality【质量】 | Evaluated by Western Blot in HeLa nuclear extract. Western Blot Analysis: 0.5 µg/mL of this antibody detected Thyroid Hormone receptor β-1 on 10 µg of HeLa nuclear extract. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control HeLa nuclear extract |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | mouse, human |
| species reactivity (predicted by homology) | rat (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_000452 |
| UniProt accession no.【UniProt登记号】 | P10828 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~60 kDa observed. An uncharacterized band may be observed at ~45 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
