PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 μg

32160405

NA.32

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.
Product Source: Coexpressed by baculovirus in Sf21 insect cells.
The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

Research Category
Inflammation & Immunology

Protein Target: PI3Kα/p85α
Target Sub-Family: PI3K/PI4K

Ni²⁺/NTA-agarose

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

300
100

mouse

M_w 129 kDa (p110α; H1047R)
M_w 83.6 kDa (p85α)

Upstate^®

activity assay: suitable (kinase)

NM_006218.2

P42336

mouse ... PIK3CA(18706)

Also available in 250μg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250μg size.

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

GHS07

Warning

H317

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Skin Sens. 1

12 - Non Combustible Liquids

WGK 2