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PIM2, active, GST tagged human
| 产品编号： | 4094091 |
| 规格： | PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| NACRES | NA.32 |
| Application【应用】 | PIM2, active, GST tagged human has been used for in vitro kinase assay in study of PIM kinases role in fms-like tyrosine kinase 3 inhibitors (FLT3i)-resistant acute myeloid leukemia. |
| Biochem/physiol Actions【生化/生理作用】 | PIM2 (proto-oncogene) is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, testis, small instestine and colon, as well as in spleen and thymus. It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells and during meiosis. PIM2 acts as a pro-survival kinase and BAD (BCL2 associated agonist of cell death) protein is a PIM2 substrate. |
| Physical form【外形】 | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
| Legal Information【法律信息】 | PRECISIO is a registered trademark of sigma-aldrich Co. LLC |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
| product line【产品线】 | PRECISIO® Kinase |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| Specific Activity | 259-351 nmol/min·mg |
| mol wt【分子量】 | ~61 kDa |
| UniProt accession no.【UniProt登记号】 | Q9P1W9 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... PIM2(11040) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
