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Anti-phospho-Integrin β3 (pTyr773) antibody produced in rabbit
| 产品编号： | 4094051 |
| 规格： | affinity isolated antibody, buffered aqueous solution |
| 包装规格： | 1 VIAL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD06798492 |
| NACRES | NA.41 |
| General description【一般描述】 | The gene ITGB3 (integrin subunit β 3) encodes the β subunit of integrins, which are transmembrane α/β heterodimers. There are 18 α subunits and 8 β subunits identified in mammals that associate with each other to form 24 different heterodimers. Based on the type of β3 subunit, the heterodimers can be grouped into subfamilies. |
| Immunogen【免疫原】 | synthetic phosphopeptide derived from the region of human integrin β3 receptor that contains tyrosine 773. The sequence is conserved in human, mouse, and rat. |
| Biochem/physiol Actions【生化/生理作用】 | Integrins function in various cellular processes, such as tissue migration during embryogenesis, cellular adhesion, cancer metastases, and lymphocyte helper and killer cell functions. The β3 subunit is expressed along with αv and αIIb subunits in platelets to form the subfamilies αvβ3 and αIIbβ3. The receptor αvβ3 facilitates platelet adhesion to osteopontin and vitronectin in vitro. But, it is yet to be determined if it functions in platelet adhesion in vivo. The αvβ3 receptor functions as a receptor for fibrinogen, vWF, fibronectin, and vitronectin and participates in platelet aggregation. Any defects in the number or function of this receptor may result in the inhibition of platelet aggregation, leading to the bleeding disorder Glanzmann thrombasthenia. |
| Physical form【外形】 | Solution in Dulbecco′s PBS, containing 1 mg/mL BSA, 50% Glycerol. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 200 |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen 130 kDa |
| species reactivity | human, mouse, rat |
| technique(s) | western blot: 0.1-1.0 μg/mL using K562 cells |
| UniProt accession no.【UniProt登记号】 | P05106 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... ITGB3(3690) mouse ... Itgb3(16416) rat ... Itgb3(29302) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
