InsR (1011-end), active, GST tagged human

NA.32

INSR (insulin receptor) belongs to the receptor tyrosine kinase family and is a cell surface receptor. Insulin binding to INSR results in autophosphorylation and increased catalytic activity. These events are important for downstream signalling. Insulin/INSR signaling is crucial in the central nervous system for controlling blood glucose levels, synaptic plasticity, dendritic growth, regulation of electrophysiological activity, astrocytes proliferation and neuronal cell death. Mutations in INSR are associated with hyperinsulinemic hypoglycemia syndrome.

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

200

expressed in baculovirus infected Sf9 cells

PRECISIO^® Kinase

≥70% (SDS-PAGE)

buffered aqueous glycerol solution

2281-3086 nmol/min·mg

~70 kDa

P06213

dry ice

−70℃

human ... INSR(3643)

10 - Combustible liquids

WGK 1

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)