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Anti-ASCIZ Antibody
| 产品编号： | 4093910 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-ASCIZ Antibody
ATM interactor, ATM/ATR-substrate CHK2-interacting zinc finger protein, ASCIZ, Zinc finger protein 822
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | ASCIZ is a transcription factor that interacts with the potent kinase ATM and regulates its activity and stability. ATM is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signaling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets. ASCIZ plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage as well. ASCIZ is also critical in development. Knockouts are lethal at E16 and show severe organ developmental defects, including a complete absence of lungs similar to mutants in Wnt2-2b/ß-catenin and FGF10/FGFR2b signaling pathways. Thus, ASCIZ has dual functions as an efficiency factor for DNA base damage repair as well as a key transcriptional regulator of early lung development. ASCIZ is localized to the nucleus in discrete foci during G1 and is ubiquitously expressed in normal and cancerous tissues. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human ASCIZ required for formation of RAD51 foci. Epitope: Required for formation of RAD51 foci |
| Application【应用】 | Anti-ASCIZ is an antibody against ASCIZ for use in Western Blotting. |
| Quality【质量】 | Evaluated by Western Blotting in human skeletal muscle tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected ASCIZ in 10 µg of human skeletal muscle tissue lysate. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, human, mouse |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_056066 |
| UniProt accession no.【UniProt登记号】 | O43313 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~100/120 kDa observed. Uncharacterized band(s) may appear in some lysates. |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
