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Histone H1 human

产品编号:4093838
CAS NO:1523001-32-2
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
4093838100 μG1190
产品别名

1523001-32-2

Histone H1 human

Histone, Human

基本信息
NACRES
NA.25
General description【一般描述】
Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.
Biochem/physiol Actions【生化/生理作用】
The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.
Physical form【外形】
Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.
产品性质
Quality Level【质量水平】
200
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
form【形式】
liquid
concentration【浓度】
1 mg/mL
UniProt accession no.【UniProt登记号】
P07305
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... H1.0(3005)
安全信息
Pictograms【象形图】
GHS07
Signal word【警示用语:】
Warning
Hazard Statements
H319
Precautionary Statements
P264 - P280 - P305 + P351 + P338 - P337 + P313
Hazard Classifications【危险分类】
Eye Irrit. 2
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
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