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Antipain, Dihydrochloride-CAS 37682-72-7-Calbiochem

产品编号:4091023
规格:Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes.
CAS NO:37682-72-7
包装规格:10 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
409102310 MG1940
产品别名

37682-72-7

Antipain, Dihydrochloride-CAS 37682-72-7-Calbiochem

基本信息
Empirical Formula【经验(实验)分子式】
C27H44N10O6 · 2HCl
Molecular weight
677.62
MDL number
MFCD00135957
General description【一般描述】
Effective concentration: 1-100 µM.
A reversible protease inhibitor produced by actinomycetes. Inhibits cathepsin A and B as well as papain, and trypsin-like serine proteases. Acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Effective at concentrations range from 1 to 100 µM.
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca2+-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC50 = 300 µM).
Biochem/physiol Actions【生化/生理作用】
Target IC50: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases; Effective concentration: 1-100 µM
Product does not compete with ATP.
Cell permeable: no
Reversible: yes
Primary Target
trypsin-like serine proteases, papain, and some cysteine proteases
Warning【警告】
Toxicity: Standard Handling (A)
Reconstitution【重悬】
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Other Notes【其他说明】
Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Ichikawa, S., et al. 1985. J. Reprod. Fertil.73, 385
Umezawa, H. 1976. Methods Enzymol.55, 678.
Suda, H., et al. 1972. J. Antibiot. (Tokyo) 25, 263.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥97% (HPLC)
form【形式】
powder
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
desiccated (hygroscopic)
protect from light
color【颜色】
white
solubility【溶解性】
water: 1 mg/mL
DMSO: 5 mg/mL
shipped in【运输】
ambient
storage temp.【储存温度】
2-8℃
InChI
1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1
InChI key
GXQPAKIVOCLCHD-BXLPLHKWSA-N
packaging【包装】
10 mg in Plastic ampoule
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 3
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