ZAP-70 Tyrosine Kinase human

MFCD03459122

NA.32

Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.

ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.
ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.

One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 ℃ at pH 7.0.

Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.

200

expressed in baculovirus infected insect cells (Histidine tagged)

≥90% (SDS-PAGE)

buffered aqueous glycerol solution

≥150 U/mg

70 kDa

P43403

dry ice

−70℃

human ... ZAP70(7535)

10 - Combustible liquids

WGK 1