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AURORA B，活性，GST 标记 人
AURORA B, active, GST tagged human
| 产品编号： | 4090327 |
| 规格： | PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
AURORA B，活性，GST 标记 人
AURORA B, active, GST tagged human
IPL1
AIK2
AIM1
Stk12
AurB
ARK2
AURKB
基本信息
| NACRES | NA.32 |
| Biochem/physiol Actions【生化/生理作用】 | AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92.This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype. |
| Physical form【外形】 | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
| Legal Information【法律信息】 | PRECISIO is a registered trademark of sigma-aldrich Co. LLC |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in baculovirus infected Sf9 cells |
| product line【产品线】 | PRECISIO® Kinase |
| Assay【测定】 | ≥70% (SDS-PAGE) |
| form【形式】 | buffered aqueous glycerol solution |
| Specific Activity | 162-219 nmol/min·mg |
| mol wt【分子量】 | ~68 kDa |
| UniProt accession no.【UniProt登记号】 | Q96GD4 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... AURKB(9212) |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
