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产品别名
Anti-CDT1 Antibody
DNA replication factor , Double parked homolog , Double parked, Drosophila, homolog of 2 chromatin licensing and DNA replication factor 1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | CDT1 (Chromatin Licensing and DNA replication Factor 1) is an essential component of the cell cycle machinery. It plays an important role in insuring that there is only one round of DNA replication per cell cycle. CDT1 is a known substrate of Cdk2 and Cdk4 (Liu, E. 2004). It is presented in G1 of the cell cycle and is degraded as cells enter S phase (Liu, E. 2004). In higher eukaryotes, CDT1 is known to interact with Geminin, a protein that is degraded during mitosis, that inhibits it. CDT1 is marked for degradation by two E3 ligases: SCF complex and the CUL4-DDB1 complex (Sansam, 2006). |
| Specificity【特异性】 | This antibody recognizes the Cdt1. |
| Immunogen【免疫原】 | Epitope: C-terminal half Recombinant protein including amino acids 238-546 of human CDT1. |
| Application【应用】 | Research Sub Category Cell Cycle, DNA Replication & Repair An independent lab detected this antibody to immunoprecipitate (IP) Cdt1 using 2 μL/IP reaction (Wohlschlegel, B.T., 2000). Detect CDT1 using this Anti-CDT1 Antibody validated for use in WB & IP. Research Category Signaling |
| Quality【质量】 | Evaluated by western blot on Jurkat cell lysate. Western Blot Analysis: 1:1,000 dilution of this antibody was used to detect CDT1 in Jurkat cell lysate. |
| Physical form【外形】 | Unpurified rabbit serum containing 0.05% NaN3. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | serum |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| species reactivity | rat, human, mouse |
| technique(s) | immunoprecipitation (IP): suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_112190.2 |
| UniProt accession no.【UniProt登记号】 | Q9H211 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 65 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 2 years at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
