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Matrix Metalloproteinase-7 human
| 产品编号： | 4087303 |
| 规格： | ~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution |
| 包装规格： | 10 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Matrix Metalloproteinase-7 human
MMP-7
Matrilysin-1
基本信息
| Enzyme Commission (EC) Number【酶学委员会(EC)编号】 | 3.4.24.23 ( BRENDA | IUBMB ) |
| MDL number | MFCD01633460 |
| NACRES | NA.32 |
| General description【一般描述】 | Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells. |
| Application【应用】 | Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan. |
| Biochem/physiol Actions【生化/生理作用】 | Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion. |
| Physical form【外形】 | Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl |
| Analysis Note【分析说明】 | One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 ℃. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| form【形式】 | buffered aqueous solution |
| Specific Activity | 5,000 units/mg protein |
| mol wt【分子量】 | 20 kDa |
| concentration【浓度】 | ~0.1 mg/mL |
| UniProt accession no.【UniProt登记号】 | P09237 |
| relevant disease(s)【相关疾病】 | cancer |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... MMP7(4316) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
