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S4
产品别名
1330061-67-0
S4
4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamic acid ester
4-[(3,5-Dimethylphenyl)ureido]phenyl sulfamate
4-(3′-(3″,5″-Dimethylphenyl)ureido)phenyl sulfamate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H17N3O4S |
| Molecular weight | 335.38 |
| MDL number | MFCD30182321 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | S4 is a potent and selective inhibitor against sulfamate carbonic anhydrase (CA) subtypes CAIX & CAXII (Ki = 2, 7, 546, 5600 nM against human CA XII, IX, II, and I, respectively). S4 selectively inhibits migration upon anoxia/hypoxia-induced CAIX expression in cancer cultures (% inhibition/conc./cell line = 54%/100 μM/WRO, 65%/33 μM/MDA-MB-231), while exhibiting no inhibitory effects under normoxia or among non-CAIX-expressing cells (HCT116 & RT112). Daily intraperitoneal injection (10 mg/kg) is reported to reduce the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors in vivo. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=S(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(N)=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
