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Phenanthriplatin
产品别名
Phenanthriplatin
PhenPt
(SP-4-3)-Diamminechlorido(phenanthridine)platinum(II) nitrate
cis-[Pt(NH3)2(phenanthridine)Cl]NO3
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C13H15ClN4O3Pt |
| Molecular weight | 505.81 |
| Biochem/physiol Actions【生化/生理作用】 | Phenanthriplatin is a cationic monofunctional DNA-binding platinum (II) complex with significantly greater anticancer activity (IC50 in μM = 0.035/Ntera2, 0.22/A549, 0.30/HeLa, 0.59/U2OS, 0.74/PC3, 0.94/MCF7, 2.02/HT29; 72 h, MTT assay) than cisplatin, oxaliplatin, and pyriplatin. Enhanced cellular uptake due to its hydrophobic phenanthridine ligand as well as more rapid DNA covalent-binding activity both contribute to its superior anticancer efficacy. Phenanthriplatin binds more effectively to 5′-deoxyguanosine monophosphate than to N-acetyl methionine, whereas pyriplatin reacts equally to both. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | >97% (NMR) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl[Pt](N)([N+]1=C2C=CC=CC2=C3C=CC=CC3=C1)N.[O-][N+]([O-])=O |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
