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PF-06807656
产品别名
PF-06807656
(-)-3-(N-(4-Chlorophenyl)sulfamoyl)-4-methoxy-N-(1-(2-methyl-2H-1,2,3-triazol-4-yl)ethyl)benzamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C19H20ClN5O4S |
| Molecular weight | 449.91 |
| Biochem/physiol Actions【生化/生理作用】 | PF-06807656 is a 3-sulfamoylbenzamide-based renal outer medullary potassium channel (ROMK, CCNJ1, Kir1.1) inhibitor (IC50 = 61 nM by whole cell patch clamp) that is insensitive to K80M or N171D pore mutation and exhibits high selectivity for human over rat species (IC50 against thallium sulfate/TlSO4-stimulated influx = 391 nM vs. >30 μM using human or rat ROMK1-expressing HEK293 cells; 82% vs. 0% inhibition by patch clamp using human or rat ROMK2-expressing HEK293 cells). |
| Legal Information【法律信息】 | Sold for research purposes under agreement from Pfizer Inc. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(NC(C1=NN(C)N=C1)C)C(C=C2S(=O)(NC3=CC=C(Cl)C=C3)=O)=CC=C2OC |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
