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Peretinoin
产品别名
81485-25-8
Peretinoin
(2E,4E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,4,6,10,14-pentaenoic acid
E-5166
NIK-333
ACR
3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
Acyclic retinoid
Polyprenoic acid
all-trans-3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
K 333
NIK 333
E 5166
K333
E5166
K-333
NIK333
4,5-Didehydrogeranyl geranoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H30O2 |
| Molecular weight | 302.45 |
| MDL number | MFCD01742209 |
| Biochem/physiol Actions【生化/生理作用】 | Peretinoin is an orally active synthetic acyclic retinoid (ACR) whose in vivo anti-hepatocellular carcinoma (HCC) efficacy is attributed to its upregulatory activity toward retinoid nuclear receptors (RARbeta & RXRalpha), as well as negative regulation against sphingosine kinase 1 (SPHK1) expression and, thereby, sphingosine metabolic pathway. Peretinoin inhibits the replication of hepatitis B & C viruses in cultures (HBV & HCV EC50 = 9-25 μM) and shows in vivo efficacy in rodent models of hepatocarcinogenesis among rats (10, 40, or 80 mg/kg/day p.o.) and mice (0.03% or 0.06% in diet) subjected to chronic inflammation induction by diethylnitrosamine (DEN). |
产品性质
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
