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NSC49652
产品别名
908563-68-8
NSC49652
(E)-1-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-2-propen-1-one
(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H11NO2 |
| Molecular weight | 225.24 |
| MDL number | MFCD00499170 |
| Biochem/physiol Actions【生化/生理作用】 | NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) that targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
