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cis-22a
产品别名
1819366-84-1
cis-22a
1-[cis-4-(3-Methylphenyl)cyclohexyl]-4-(3-pyridinyl)piperazine, trifluoroacetate (1:2)
cis-1-(4-(3-Methylphenyl)cyclohexyl)-4-((pyridin-4-yl)methyl)piperazine, trifluoroacetate (1:2)
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H29N3 · 2CF3CO2H |
| Molecular weight | 563.53 |
| Biochem/physiol Actions【生化/生理作用】 | cis-22a is a potent and highly selective TrpV6 (CaT1, ECaC2) inhibitor (Cd2+ influx IC50 = 320 nM; hTRPV6 transfected HEK293) with much reduced and little potency against other calcium channels and related TRP targets. cis-22a selectively inhibits the growth of TrpV6-expressing breast cancer T47D (IC50 = 25 μM), but not TrpV6-negative ovarian carcinoma SKOV3 cultures (IC50 >50 μM). |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | H2O: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1=CC=CC([C@H]2CC[C@@H](N3CCN(C4=CN=CC=C4)CC3)CC2)=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
